Table of contentsNew Treatments in COPD Frank P Hull, MD FAASM Slide 2 Emphysema is an anatomic diagnosis while Chronic Bronchitis is clinical diagnosis. Spectrum of Disease Different Diseases, Different Inflammatory Mediators Slide 6 Risk Factors COPD If exposure to noxious agents stops, disease may still progress Slide 9 Presentation Slide 11 Changing Epidemiology: Quick Facts Inflammatory Process in COPD Slide 14 Reduced expiratory flow rate, destruction of alveoli, and short exhalation time lead to… Patients Are Much More Diverse3 COPD Deaths are increasing in men and women Patients Are Much More Diverse2 Younger Patients are becoming more common. Patients Are Much More Diverse1 Women can get COPD with less smoking. Presumptive Diagnosis Differential Diagnosis Mucous Glands hypertophy in chronic bronchitis. Slide 25 Slide 26 Diagnosis of COPD Role of Spirometry Slide 28 Lung Volumes in Obstructive Disease Slide 30 Slide 31 GOLD Stages of COPD Patient Diagnosis: Angie (47-Year-Old Female) Patient Diagnosis: Brad (53-Year-Old Male) Patient Diagnosis: Carmen (55-Year-Old Female) Mechanisms of Dyspnea in COPD Basic Goals of COPD Management Treatment and management options in COPD Slide 39 Oxygen therapy Slide 41 Slide 42 Lung Transplant Slide 44 Four Components of COPD Management Step-up Therapy Muscarinic Receptor Subtypes in Airways Cholinergic Pathways Cholinergic Tone in the Airways Effect of Anticholinergic Drugs Bronchodilator Therapy in COPD Bronchodilators that inhibit Cholinergic Tone Simpathetic Tone Non-Selective Simpathamimetics Beta 2 Selective Bronchodilators Beta 2 Agonists may be dangerous “The Serevent Black Box warning” Ipratropium vs Metaproterenol in COPD FEV1: Ipratropium vs Metaproterenol in COPD FVC: Ipratropium vs Metaproterenol in COPD Ipratropium vs Albuterol vs COMBIVENT® in COPD Mean Change in FEV1* Disease Exacerbations Prevention of Exacerbations Number of Patient Days of Exacerbation Total Hospital Days for Exacerbations Slide 66 Slide 67 Slide 68 Slide 69 Slide 70 Slide 71 Slide 72 Slide 73 Slide 74 Slide 75 Slide 76 Slide 77 Slide 78 Slide 79 Slide 80 Slide 81 |
Author: Frank Hull E-mail: frankhull@yahoo.com Homepage: http://www.browardsleepdisorders.com/ |