Frank Hull, M.D.
Overview of Obstructive Lung Diseases
Spectrum of Disease
Presentation
Emphysema is an anatomic diagnosis while Chronic Bronchitis is a clinical diagnosis.
COPD Patients—the Stereotype
PPT Slide
Emphysema case presentation:
Emphysema continued:
Alveolar Destruction
Chronic Bronchitis case presentation:
Chronic bronchitis continued
Mucous Glands Hypertophy in Chronic Bronchitis.
Inflammatory Process in COPD
Histopathologic Features of COPD
Differential Diagnosis of COPD
Different Diseases, Different Inflammatory Mediators
Causes of COPD
Risk factors for COPD
Symptoms of COPD
Small Airway Narrowing
Shortness of Breath (SOB)/Dypnea
COPD Impairs the Pts. activities
Psychosocial Effects
Other significant effects of COPD
Burden of COPD
Burden of COPD (cont)
Presumptive Diagnosis of COPD
COPD Patients—Not Necessarily the Stereotype
COPD deaths are increasing in men and women
Younger patients are becoming more common.
Women may get COPD with less smoking history.
Women now have higher prevalence rates than men for COPD
Diagnosis of COPD Role of Spirometry
Flow Volume Loops
Lung Volumes in Obstructive Disease
Reduced expiratory flow rate, destruction of alveoli, and short exhalation time lead to…
Cholinergic Tone
Muscarinic Receptor Subtypes in Airways
Effects of Anticholinergic Drugs
Disease Exacerbations
Conclusions
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